Single-Cell Transcriptome Analysis of Mouse Embryonic Development
Authors
Jane Doe1,2, John Smith1, Alan Johnson2, Sarah Williams1,3
1Department of Developmental Biology, University of Science
2Institute for Genomic Research
3Center for Computational Biology
Abstract
The development of the mammalian embryo involves complex cell fate decisions that establish the body plan. Here, we performed single-cell RNA sequencing on mouse embryos from stages E9.5 and E14.5 to profile transcriptional dynamics during development. We identified key developmental trajectories and gene expression signatures that define emerging cell types. Our analysis revealed novel markers for progenitor populations and provided insights into the regulatory networks controlling cell differentiation. This dataset serves as a valuable resource for understanding mammalian embryogenesis and cell lineage specification.
Explore Study Data
Access and visualize the two key datasets from our research
E9.5 Embryonic Dataset
Early embryonic development stage
Single-cell RNA sequencing data from E9.5 mouse embryos, capturing the transcriptional profiles of developmental precursors and early differentiating cell populations. This dataset includes 14,392 cells across multiple embryonic regions.
Later Stage Development
Organogenesis and tissue specification
This dataset contains cells from E14.5 mouse embryos, focusing on organ development and tissue specification. It includes 18,723 cells with annotated cell types representing major organ systems during mid-gestation development.
How to Cite
Doe J, Smith J, Johnson A, Williams S. Single-Cell Transcriptome Analysis of Mouse Embryonic Development. Nature Communications. 2023;14:1234. DOI: 10.1038/s41467-023-12345-6